You can compare TIFF files and see where they differ. You can compare 1-bit TIFF files, 8-bit TIFF files, and composite TIFF files (all separations of a job with the separations of another job).
VPS+ will display a comparison image of the two files that you select.
You can control the tolerance of the comparison—that is, you can decide at what level of difference the comparison should run and at what level the software notifies you that the compared files are identical. To change the tolerance, set the Comparison tolerance in Advanced preferences.